Your higher self can never be against you. The worst thing that can happen is that it could ignore you when you call, and it could withdraw it’s protection but it will not deliberately turn against you.
Yes, it 100% is possible and i know a number of people both in and out of magick who have done this.
A hypnotist i know once put a subject into somnambulism and forgot to tell their subject’s high self to recede. When they came out of the session, the high self didn’t like the decisions that person made in their daily life, and caused them all types of trouble.
I once put a trend down for someone who wronged a friend to punish the person based on it knowing that person willingly violated the person. It didn’t go well for that person. I don’t know if they’re still around.
If your high self feels you’re living wrong, it can and will punish you, up to and including the point of permanent injury or even death. As long as you’re in the wrong, you have little to no recourse.