In the Bible (the OT), YHWH promised to curse the descendants of those people who were in Covenant with him but disobeyed. I think that it is a given that he is powerful enough to carry through with that threat. Being a former Christian, I may be hosed in that way (although I’m optimistic of breaking free).
What I am curious about is similar curses that may exist in magickal circles (especially the darker forms like Palo, Hatian Voodon, and other African shit). Is there hope for those people who have been cursed?